A couple of months ago Reuters released the findings of a study reported in the Archives of Surgery, touting that weight loss surgery as a miracle cure for diabetes. As a diabetes educator I feel that this may be somewhat misleading and to be fair, I feel there is a “rest of the story” that needs to be added.
First, let’s define diabetes. Diabetes is simply an imbalance of supply and demand of insulin. Insulin is a hormone that allows glucose (the type of sugar that the body uses for fuel) to get from the blood to the muscle cells. Insulin works like a pump at the gas station. Without insulin, you will literally starve to death no matter how much you eat. This is because no matter how much sugar you have in the blood to use as fuel, you can’t get it from the gas station to the car. Type 1 diabetes is a problem with supply of insulin. No matter how much is eaten, without insulin the sugar hits a road block and ends up in the toilet rather than the muscle. This is why people with type 1 diabetes lose weight. Without insulin the only thing that can be burned as fuel is fat….hence weight loss. In type 2 diabetes the most prevalent problem is usually demand. Rather than being a problem that the body can no longer produce insulin, it is usually more of a problem of insulin resistance. In other words, the gas station has pumps, but they are pumping very slowly. This requires many more pumps to get the same amount of gas to the cars. The pancreas has to work overtime to get enough insulin. As long as the pancreas can keep up with the demand a person can be very insulin-resistant without having diabetes. We define diabetes as a build up of sugar in the blood when the demand is greater than the supply of insulin.
There are things that can affect supply of insulin. The most significant factor is how strong and healthy the pancreas is (largely due to genetics, but possibly impacted by injury). Pancreatitis can also decrease insulin production. Type 1 diabetes is an autoimmune disease where the body has attacked the pancreas, making it unable to produce insulin.
However some claim bariatric or weight loss surgery (WLS) is a cure for Type 2 diabetes, which is often a problem with demand for insulin more than supply. There are many things that affect demand. The more calories that are eaten, the more insulin is needed to get the sugar from blood to muscle. The type of calorie (fat, protein, carbohydrate or alcohol) also affects demand. The faster the calories turn to sugar, the faster insulin is needed ( and the harder the pancreas has to work to supply the demand.) Carbohydrates (especially if it is a sugary liquid) turns to sugar the fastest, which is why we pay most attention to them in diabetes.
Exercise helps the insulin to work harder. Exercise will not always fix insulin resistance, but it does help it. On occasion, exercise actually increases sugar as exercise will only lower sugar in the presence of insulin.
Stress makes insulin resistance worse due to hormones such as epinephrine and cortisol. Depression and anxiety, lack of sleep or poor quality of sleep will also make insulin resistance worse. Heredity also plays a big factor in insulin resistance.
Insulin resistance often leads to increased hunger and decreased energy, which leads to weight gain. The increased weight then leads to even more insulin resistance. This cycle is very difficult to break. Weight cycling (yo yo diets) also make insulin resistance worse.
Incorporating healthy lifestyle changes such as eating well, getting exercise, reducing stress, or getting enough sleep, decreases the demand of insulin. And often, improvement in these areas results in weight loss as a side effect. Improving insulin resistance leads to less hunger and more energy. So it appears that weight loss is what caused the “cure” of diabetes, when actually the activities that help insulin resistance caused both the weight loss and decreased demand of insulin. If you lose weight without lowering calories or exercise, you do not get the same decrease in demand of insulin (such as weight loss with cancer.) If you surgically remove fat, such as in liposuction, you also don’t get the decrease in demand. If you intentionally gain weight, but do it with a healthy diet and exercise, (such as a sumo wrestler might do) you do not get the increased demand. It is not the weight; it is the behavior that affects the demand of insulin. When you engage in healthy behaviors, you get the benefit with or WITHOUT weight loss. That is why even as little as a 5-7% weight loss will be beneficial in decreasing the demand. And why if you lose weight and keep it off, but now have a stable weight, the benefits in the decreased demand wane over time. This is also why it is so hard to lose more than 5-10% of the weight.
So back to the original question….does bariatric surgery “cure” diabetes? The two most common procedures currently done are: The Adjustable Banded Gastroplasty or Lap band (restricting calories) or the Roux En-Y (restricting calories and limiting absorption.) The immediate drop in calories (more so with Roux En-Y due to both decrease in food eaten and food absorbed) significantly decreases demand of insulin (less insulin is needed for less calories.) Depending on the supply and demand, this decreased demand may now make the difference between making budget or not. Therefore there are times the surgery appears to have ‘cured’ diabetes even before weight loss has occurred. Reducing calories in general such as in garden variety weight loss will produce the same effect and look like it “cures” diabetes, when in actuality it too just decreases demand. Usually with weight loss diets, the drop in calories is not as sudden and drastic and usually weight is lost before benefit is seen.
That being said, there is a lot we currently do not understand about hormones that affect appetite and metabolism. Some of these hormones such as ghrelin and GLP-1 come from the gut as a result of eating. Eating less or absorbing less has an effect on these hormones as well as hormones such as leptin that come from fat tissue. Surgical manipulation no doubt affects these hormones which is how they claim it “cures” diabetes. While I have not seen any official studies that show this, I have often seen when someone drastically and rapidly decreases calories, the same decreased demand of insulin occurs and occasionally this decreased demand “cures” diabetes with no surgery (such as going on a liquid protein Optifast type diet.)
Either way, as you get older, you need more and more insulin, and your ability to produce insulin decreases over time. Therefore as you age, the potential for an imbalance of supply and demand is still there even if it was previously “cured.” So whether weight is lost because of surgery or because of healthy changes in behaviors, there is the possibility of diabetes reoccurring.
So perhaps the more important question is which path is the best path to reducing insulin resistance and perhaps balancing the supply and demand for insulin: embracing a Health At Every Size® way of life where you meet the nutritional, physical, and emotional needs of your body even if weight is unchanged, or weight loss surgery which may have on average better weight loss but has significant side effects.
With lap band (figure 1), the fluid filled balloon around the stomach is holding constant pressure around the stomach. As the stomach fills and food moves through there is movement which leads to pressure and friction. This can lead to ulceration under the band. If this goes through to the inside of the stomach, GI contents can leak into the body cavity leading to emergency surgery and potentially lethal peritonitis. The balloon can rupture and then the effect of restriction is lost. The band needs to be “adjustable” because the size of the opening has to be exact (too big, and food goes through too fast to be beneficial and too small, food gets stuck.) They can’t make it exact due to variability in the gathers of the stomach as the purse string is pulled. This means that we have to have a port (a tube that comes to surface to either add or take away fluid to change the pressure applied). This tube can flip or twist. It is difficult to secure the band so it can also slip up and down. This can suddenly obstruct food–also requiring emergency surgery. If food is not chewed well, it can also get stuck even if the band is in the right place and is the right size. Some medication is too big to go through the band. If irritating medications such as ibuprofen get stuck it can ulcerate from the inside out.
ไม่มีความคิดเห็น:
แสดงความคิดเห็น